Mutaflor Safety Profile

“Mutaflor has shown a perfect safety record for almost a century”  – ECCO Consensus on UC: Current management

Mutaflor meets all of today’s safety requirements. The non-pathogenicity of the Mutaflor strain has been proven to the genetical level by using methods of molecular biology. The Escherichia coli strain Nissle 1917 – designated DSM 6601 in the German Collection for Microorganisms in Braunschweig – is one of the best-examined therapeutically relevant bacterial strains worldwide.

Mutaflor (E. coli strain Nissle 1917) has no pathogenic characteristics:

• No production of enterotoxins (Shiga toxins, heat-stable and heat-labile toxins)
• No production of cytotoxins (CNF)
• No enteroinvasiveness
• No pathogenic adhesion factors (e.g. no CFA I/II, P, M and S fimbriae)
• No hemolysins
• No serum resistance
• No uropathogenicity
• No antibiotic-resistance genes